Antiviral drugs specific for coronaviruses in preclinical development
Identifieur interne : 001702 ( Main/Exploration ); précédent : 001701; suivant : 001703Antiviral drugs specific for coronaviruses in preclinical development
Auteurs : Adeyemi O. Adedeji [États-Unis] ; Stefan G. Sarafianos [États-Unis]Source :
- Current Opinion in Virology [ 1879-6257 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- isolement et purification : Antiviraux.
- pharmacologie : Antiviraux.
- tendances : Découverte de médicament.
- Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Virus du SRAS, Évaluation préclinique de médicament.
English descriptors
- KwdEn :
- MESH :
- chemical , isolation & purification : Antiviral Agents.
- chemical , pharmacology : Antiviral Agents.
- drug effects : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- trends : Drug Discovery.
- Drug Evaluation, Preclinical, Humans.
Abstract
Coronaviruses are RNA viruses that cause systemic diseases in humans and animals. There are no approved drugs for the treatment of coronavirus infections. Several SARS-CoV inhibitors, with known mechanisms of action, have been identified. These inhibitors stand as promising leads for coronavirus therapeutics.
Url:
DOI: 10.1016/j.coviro.2014.06.002
PubMed: 24997250
PubMed Central: 4195804
Affiliations:
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Le document en format XML
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Adedeji</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sarafianos, Stefan G" sort="Sarafianos, Stefan G" uniqKey="Sarafianos S" first="Stefan G" last="Sarafianos">Stefan G. Sarafianos</name><affiliation wicri:level="2"><nlm:aff id="aff0010">Christopher Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Christopher Bond Life Sciences Center, University of Missouri, Columbia, MO 65211</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0015">Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, MO 65211, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, MO 65211</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff0020">Department of Biochemistry, University of Missouri, Columbia, MO 65211, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Missouri, Columbia, MO 65211</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author></analytic><series><title level="j">Current Opinion in Virology</title><idno type="ISSN">1879-6257</idno><idno type="eISSN">1879-6265</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (isolation & purification)</term><term>Antiviral Agents (pharmacology)</term><term>Drug Discovery (trends)</term><term>Drug Evaluation, Preclinical</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>SARS Virus (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux (isolement et purification)</term><term>Antiviraux (pharmacologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Découverte de médicament (tendances)</term><term>Humains</term><term>Virus du SRAS ()</term><term>Évaluation préclinique de médicament</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Découverte de médicament</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Drug Discovery</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Evaluation, Preclinical</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Virus du SRAS</term><term>Évaluation préclinique de médicament</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Coronaviruses are RNA viruses that cause systemic diseases in humans and animals.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">There are no approved drugs for the treatment of coronavirus infections.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Several SARS-CoV inhibitors, with known mechanisms of action, have been identified.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">These inhibitors stand as promising leads for coronavirus therapeutics.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. 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Feldmann</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Missouri (État)</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Adedeji, Adeyemi O" sort="Adedeji, Adeyemi O" uniqKey="Adedeji A" first="Adeyemi O" last="Adedeji">Adeyemi O. Adedeji</name></region><name sortKey="Sarafianos, Stefan G" sort="Sarafianos, Stefan G" uniqKey="Sarafianos S" first="Stefan G" last="Sarafianos">Stefan G. Sarafianos</name><name sortKey="Sarafianos, Stefan G" sort="Sarafianos, Stefan G" uniqKey="Sarafianos S" first="Stefan G" last="Sarafianos">Stefan G. Sarafianos</name><name sortKey="Sarafianos, Stefan G" sort="Sarafianos, Stefan G" uniqKey="Sarafianos S" first="Stefan G" last="Sarafianos">Stefan G. Sarafianos</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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